Spirit of the Latin America Genomics of Breast Cancer Consortium (LAGENO-BC)
The Latin American Genomics of Breast Cancer Consortium (LAGENO-BC) is a collaborative effort including a multinational team of investigators sharing knowledge and materials to facilitate breast cancer genetics research relevant to the diverse populations of Latin America and its diaspora. LAGENO-BC aims to build a large research resource of genome wide genotype data including individuals from different countries and genetic ancestry proportions to study the Latin America-specific genetic architecture of breast cancer risk and survival.
Initial specific aims of the consortium:
1) To discover susceptibility loci and advance knowledge of etiology of breast cancer overall and by subtypes, with particular emphasis on Hispanic/Latinx-specific variation.
2) To develop polygenic risk scores and integrate them with known risk factors for personalized risk assessment for breast cancer overall and by subtypes, with particular emphasis on the generalizability of polygenic risk scores to Hispanic/Latinx individuals of different ancestry proportion and country of origin.
3) To discover loci for breast cancer prognosis, long-term survival and response to treatment, with particular emphasis on ancestry-specific associations.
LAGENO-BC Coordination & Funding
The coordination and data management for the LAGENO-BC consortium is conducted through the University of California Davis with support from the National Cancer Institute (NCI: Confluence Project).